Publication: Pharmacological manipulation of L-carnitine transport into L6 cells with stable overexpression of human OCTN2
Pharmacological manipulation of L-carnitine transport into L6 cells with stable overexpression of human OCTN2
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Todesco, L., Bur, D., Brooks, H., Török, M., Landmann, L., Stieger, B., & Krähenbühl, S. (2008). Pharmacological manipulation of L-carnitine transport into L6 cells with stable overexpression of human OCTN2. Cellular and Molecular Life Sciences, 65, 1596–1608. https://doi.org/10.1007/s00018-008-8065-7
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The high-affinity Na+-dependent carnitine transporter OCTN2 (SLC22A5) has a high renal expression and reabsorbs most filtered carnitine. To gain more insight into substrate specificity of OCTN2, we overexpressed hOCTN2 in L6 cells and characterized the structural requirements of substances acting as human OCTN2 (hOCTN2) inhibitors. A 1905-bp fragment containing the hOCTN2 complete coding sequence was introduced into the pWpiresGFP vector, and L6 cells were stably transduced using a lentiviral system. The transduced L6 cells revealed i
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- Todesco, L
- Bur, D
- Brooks, H
- Török, M
- Landmann, L
- Stieger, B
- Krähenbühl, S
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Todesco, L., Bur, D., Brooks, H., Török, M., Landmann, L., Stieger, B., & Krähenbühl, S. (2008). Pharmacological manipulation of L-carnitine transport into L6 cells with stable overexpression of human OCTN2. Cellular and Molecular Life Sciences, 65, 1596–1608. https://doi.org/10.1007/s00018-008-8065-7
