Publication: Striatal structure and its association with N-Acetylaspartate and glutamate in autism spectrum disorder and obsessive compulsive disorder
Striatal structure and its association with N-Acetylaspartate and glutamate in autism spectrum disorder and obsessive compulsive disorder
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Naaijen, J., Zwiers, M. P., Forde, N. J., Williams, S. C. R., Durston, S., Brandeis, D., Glennon, J. C., The Tactics Consortium, Franke, B., Lythgoe, D. J., & Buitelaar, J. K. (2018). Striatal structure and its association with N-Acetylaspartate and glutamate in autism spectrum disorder and obsessive compulsive disorder. European Neuropsychopharmacology, 28(1), 118–129. https://doi.org/10.1016/j.euroneuro.2017.11.010
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Autism spectrum disorders (ASD) and obsessive compulsive disorder (OCD) are often comorbid and are associated with changes in striatal volumes and N-Acetylaspartate (NAA) and glutamate levels. Here, we investigated the relation between dorsal striatal volume and NAA and glutamate levels. We additionally compared striatal volume and shape between ASD, OCD and controls. T1-weighted magnetic resonance (MR) images, proton spectra (1H-MRS) in the left striatum, and phenotypic information were collected from 54 children with ASD, 32 with OC
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- Naaijen, Jilly
- Zwiers, Marcel P
- Forde, Natalie J
- Williams, Steven C R
- Durston, Sarah
- Brandeis, Daniel
- Glennon, Jeffrey C
- The Tactics Consortium
- Franke, Barbara
- Lythgoe, David J
- Buitelaar, Jan K
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Naaijen, J., Zwiers, M. P., Forde, N. J., Williams, S. C. R., Durston, S., Brandeis, D., Glennon, J. C., The Tactics Consortium, Franke, B., Lythgoe, D. J., & Buitelaar, J. K. (2018). Striatal structure and its association with N-Acetylaspartate and glutamate in autism spectrum disorder and obsessive compulsive disorder. European Neuropsychopharmacology, 28(1), 118–129. https://doi.org/10.1016/j.euroneuro.2017.11.010