COMPULS: design of a multicenter phenotypic, cognitive, genetic, and magnetic resonance imaging study in children with compulsive syndromes

Naaijen, Jilly; de Ruiter, Saskia; Zwiers, Marcel P; Glennon, Jeffrey C; Durston, Sarah; Lythgoe, David J; Williams, Steven C R; Banaschewski, Tobias; Brandeis, Daniel; Franke, Barbara; Buitelaar, Jan K

doi:10.1186/s12888-016-1072-6

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Naaijen, J., de Ruiter, S., Zwiers, M. P., Glennon, J. C., Durston, S., Lythgoe, D. J., Williams, S. C. R., Banaschewski, T., Brandeis, D., Franke, B., & Buitelaar, J. K. (2016). COMPULS: design of a multicenter phenotypic, cognitive, genetic, and magnetic resonance imaging study in children with compulsive syndromes. BMC Psychiatry, 16(1), 361. https://doi.org/10.1186/s12888-016-1072-6

Abstract

Background: Compulsivity, the closely linked trait impulsivity and addictive behaviour are associated with several neurodevelopmental disorders, including attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive compulsive disorder (OCD). All three disorders show impaired fronto-striatal functioning, which may be related to altered glutamatergic signalling. Genetic factors are also thought to play an important role in the aetiology of compulsivity-related disorders. Methods: The COMPULS study is a