Publication: Nuclear actin polymerization rapidly mediates replication fork remodeling upon stress by limiting PrimPol activity
Nuclear actin polymerization rapidly mediates replication fork remodeling upon stress by limiting PrimPol activity
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Palumbieri, M. D., Merigliano, C., González-Acosta, D., Kuster, D., Krietsch, J., Stoy, H., von Känel, T., Ulferts, S., Welter, B., Frey, J., Doerdelmann, C., Sanchi, A., Grosse, R., Chiolo, I., & Lopes, M. (2023). Nuclear actin polymerization rapidly mediates replication fork remodeling upon stress by limiting PrimPol activity. Nature Communications, 14(1), 7819. https://doi.org/10.1038/s41467-023-43183-5
Abstract
Abstract
Abstract
Cells rapidly respond to replication stress actively slowing fork progression and inducing fork reversal. How replication fork plasticity is achieved in the context of nuclear organization is currently unknown. Using nuclear actin probes in living and fixed cells, we visualized nuclear actin filaments in unperturbed S phase and observed their rapid extension in number and length upon genotoxic treatments, frequently taking contact with replication factories. Chemically or genetically impairing nuclear actin polymerization shortly befo
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Creators (Authors)
- Palumbieri, Maria Dilia
- Merigliano, Chiara
- González-Acosta, Daniel
- Kuster, Danina
- Krietsch, Jana
- Stoy, Henriette
- von Känel, Thomas
- Ulferts, Svenja
- Welter, Bettina
- Frey, Joël
- Doerdelmann, Cyril
- Sanchi, Andrea
- Grosse, Robert
- Chiolo, Irene
- Lopes, Massimo
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Palumbieri, M. D., Merigliano, C., González-Acosta, D., Kuster, D., Krietsch, J., Stoy, H., von Känel, T., Ulferts, S., Welter, B., Frey, J., Doerdelmann, C., Sanchi, A., Grosse, R., Chiolo, I., & Lopes, M. (2023). Nuclear actin polymerization rapidly mediates replication fork remodeling upon stress by limiting PrimPol activity. Nature Communications, 14(1), 7819. https://doi.org/10.1038/s41467-023-43183-5
