Publication: An amygdalar neural ensemble that encodes the unpleasantness of pain
An amygdalar neural ensemble that encodes the unpleasantness of pain
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Corder, G., Ahanonu, B., Grewe, B. F., Wang, D., Schnitzer, M. J., & Scherrer, G. (2019). An amygdalar neural ensemble that encodes the unpleasantness of pain. Science, 363(6424), 276–281. https://doi.org/10.1126/science.aap8586
Abstract
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Abstract
Pain is an unpleasant experience. How the brain’s affective neural circuits attribute this aversive quality to nociceptive information remains unknown. By means of time-lapse in vivo calcium imaging and neural activity manipulation in freely behaving mice encountering noxious stimuli, we identified a distinct neural ensemble in the basolateral amygdala that encodes the negative affective valence of pain. Silencing this nociceptive ensemble alleviated pain affective-motivational behaviors without altering the detection of noxious stimu
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- Corder, Gregory
- Ahanonu, Biafra
- Grewe, Benjamin F
- Wang, Dong
- Schnitzer, Mark J
- Scherrer, Grégory
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Corder, G., Ahanonu, B., Grewe, B. F., Wang, D., Schnitzer, M. J., & Scherrer, G. (2019). An amygdalar neural ensemble that encodes the unpleasantness of pain. Science, 363(6424), 276–281. https://doi.org/10.1126/science.aap8586