Identification of Novel Factors and Mechanisms regulating the Mitotic DNA Damage Response

Abstract

DNA double strand breaks (DSBs) are amongst the most toxic and dangerous lesions and can therefore severely threaten the integrity of our genome. The DNA damage response (DDR) pathway evolved to promptly signal and repair DSBs by initiating a series of chromatin remodeling events and recruiting many DNA repair factors to the site of lesion. Depending on the cell cycle phase, cells can take advantage of two main pathways for repair of the broken chromosome ends. The non-homologous end joining (NHEJ) is mainly active in G1 and early-S p Show more