Publication: Unexpected survival of mice carrying a mutation in Pygo2 that strongly reduces its binding to Bcl9/9l
Unexpected survival of mice carrying a mutation in Pygo2 that strongly reduces its binding to Bcl9/9l
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Cantù, C., Zimmerli, D., & Basler, K. (2016). Unexpected survival of mice carrying a mutation in Pygo2 that strongly reduces its binding to Bcl9/9l. Matters Select, 1–5. https://doi.org/10.19185/matters.201604000006
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Pygopus is a transcriptional activator important for the Wnt signaling pathway. It binds to the beta-catenin transcriptional complex via the adaptor proteins Bcl9 and Bcl9l (Bcl9/9l). This complex is considered to be a suitable target for the treatment of tumors that display activated Wnt signaling. In the mouse, there are two Pygopus-encoding genes, Pygo1 and Pygo2 (Pygo1/2), with the latter playing a major role. Here we introduce a single amino acid substitution in Pygo2, which was previously shown to abrogate binding to Bcl9/9l, an
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Cantù, C., Zimmerli, D., & Basler, K. (2016). Unexpected survival of mice carrying a mutation in Pygo2 that strongly reduces its binding to Bcl9/9l. Matters Select, 1–5. https://doi.org/10.19185/matters.201604000006
