Publication: Natural genetic variation differentially affects the proteome and transcriptome in Caenorhabditis elegans
Natural genetic variation differentially affects the proteome and transcriptome in Caenorhabditis elegans
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Kamkina, P., Snoek, L. B., Grossmann, J., Volkers, R. J. M., Sterken, M. G., Daube, M., Roschitzki, B., Fortes, C., Schlapbach, R., Roth, A., von Mering, C., Hengartner, M. O., Schrimpf, S. P., & Kammenga, J. E. (2016). Natural genetic variation differentially affects the proteome and transcriptome in Caenorhabditis elegans. Molecular & Cellular Proteomics, 15(5), 1670–1680. https://doi.org/10.1074/mcp.M115.052548
Abstract
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Abstract
Natural genetic variation is the raw material of evolution and influences disease development and progression. An important question is how this genetic variation translates into variation in protein abundance. To analyze the effects of the genetic background on gene and protein expression in the nematode Caenorhabditis elegans, we quantitatively compared the two genetically highly divergent wild-type strains N2 and CB4856. Gene expression was analyzed by microarray assays, and proteins were quantified using stable isotope labeling by
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- Kamkina, Polina
- Snoek, L Basten
- Grossmann, Jonas
- Volkers, Rita J M
- Sterken, Mark G
- Daube, Michael
- Roschitzki, Bernd
- Fortes, Claudia
- Schlapbach, Ralph
- Roth, Alexander
- Hengartner, Michael O
- Schrimpf, Sabine P
- Kammenga, Jan E
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European Community Health Seventh Framework Programme FP7/2007-2013
Swiss National Science Foundation
Kanton of Zurich
Netherlands Organization for Scientific Research
NWO-ALW
Graduate School Production Ecology and Resource Conservation
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Kamkina, P., Snoek, L. B., Grossmann, J., Volkers, R. J. M., Sterken, M. G., Daube, M., Roschitzki, B., Fortes, C., Schlapbach, R., Roth, A., von Mering, C., Hengartner, M. O., Schrimpf, S. P., & Kammenga, J. E. (2016). Natural genetic variation differentially affects the proteome and transcriptome in Caenorhabditis elegans. Molecular & Cellular Proteomics, 15(5), 1670–1680. https://doi.org/10.1074/mcp.M115.052548
