Publication: Activation of NF-κB via Endosomal Toll-like Receptor 7 (TLR7)or TLR9 Suppresses Murine Herpes Virus 68 Reactivation
Activation of NF-κB via Endosomal Toll-like Receptor 7 (TLR7)or TLR9 Suppresses Murine Herpes Virus 68 Reactivation
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Haas, F., Yamauchi, K., Murat, M., Bernasconi, M., Yamanaka, N., Speck, R. F., & Nadal, D. (2014). Activation of NF-κB via Endosomal Toll-like Receptor 7 (TLR7)or TLR9 Suppresses Murine Herpes Virus 68 Reactivation. Journal of Virology, 88(17), 10002–10012. https://doi.org/10.1128/JVI.01486-14
Abstract
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In order to understand and possibly treat B-cell malignancies associated with latent gamma-herpesvirus infection, it is vital to understand the factors that control the balance between the two transcriptional states of gamma-herpesviruses: latency and lytic replication. We used murine gamma-herpesvirus (MHV)-68 as a model system to investigate how engagement of endosomal Toll-like receptors (TLRs) impacts on reactivation from latency in vitro and on establishment of latent infection in vivo. We found that treatment with TLR7 ligand R8
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Creators (Authors)
- Haas, Florian
- Yamauchi, Kazuma
- Murat, Monika
- Bernasconi, Michele
- Yamanaka, Noboru
- Speck, Roberto F
- Nadal, David
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Citations
Haas, F., Yamauchi, K., Murat, M., Bernasconi, M., Yamanaka, N., Speck, R. F., & Nadal, D. (2014). Activation of NF-κB via Endosomal Toll-like Receptor 7 (TLR7)or TLR9 Suppresses Murine Herpes Virus 68 Reactivation. Journal of Virology, 88(17), 10002–10012. https://doi.org/10.1128/JVI.01486-14
