Publication: Predicting eating disorder and anxiety symptoms using disorder-specific and transdiagnostic polygenic scores for anorexia nervosa and obsessive-compulsive disorder
Predicting eating disorder and anxiety symptoms using disorder-specific and transdiagnostic polygenic scores for anorexia nervosa and obsessive-compulsive disorder
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Yilmaz, Z., Schaumberg, K., Halvorsen, M., Goodman, E. L., Brosof, L. C., Crowley, J. J., Mathews, C. A., Mattheisen, M., Breen, G., Bulik, C. M., Micali, N., Zerwas, S. C., Anorexia Nervosa Genetics Initiative, Eating Disorders Working Group of the PGC, & Tourette Syndrome/OCD Working Group of the PGC. (2023). Predicting eating disorder and anxiety symptoms using disorder-specific and transdiagnostic polygenic scores for anorexia nervosa and obsessive-compulsive disorder. Psychological Medicine, 53, 3021–3035. https://doi.org/10.1017/s0033291721005079
Abstract
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Abstract
Background: Clinical, epidemiological, and genetic findings support an overlap between eating disorders, obsessive-compulsive disorder (OCD), and anxiety symptoms. However, little research has examined the role of genetics in the expression of underlying phenotypes. We investigated whether the anorexia nervosa (AN), OCD, or AN/OCD transdiagnostic polygenic scores (PGS) predict eating disorder, OCD, and anxiety symptoms in a large developmental cohort in a sex-specific manner.
Methods: Using summary statistics from Psychiatric Genomic
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Creators (Authors)
- Yilmaz, Zeynep
- Schaumberg, Katherine
- Halvorsen, Matthew
- Goodman, Erica L
- Brosof, Leigh C
- Crowley, James J
- Mathews, Carol A
- Mattheisen, Manuel
- Breen, Gerome
- Bulik, Cynthia M
- Micali, Nadia
- Zerwas, Stephanie C
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Yilmaz, Z., Schaumberg, K., Halvorsen, M., Goodman, E. L., Brosof, L. C., Crowley, J. J., Mathews, C. A., Mattheisen, M., Breen, G., Bulik, C. M., Micali, N., Zerwas, S. C., Anorexia Nervosa Genetics Initiative, Eating Disorders Working Group of the PGC, & Tourette Syndrome/OCD Working Group of the PGC. (2023). Predicting eating disorder and anxiety symptoms using disorder-specific and transdiagnostic polygenic scores for anorexia nervosa and obsessive-compulsive disorder. Psychological Medicine, 53, 3021–3035. https://doi.org/10.1017/s0033291721005079
