Twenty-eight days of exposure to 3454 m increases mitochondrial volume density in human skeletal muscle

Jacobs, Robert A; Lundby, Anne-Kristine Meinild; Fenk, Simone; Gehrig, Saskia; Siebenmann, Christoph; Flück, Daniela; Kirk, Niels; Hilty, Matthias P; Lundby, Carsten

doi:10.5167/uzh-122927

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Jacobs, R. A., Lundby, A.-K. M., Fenk, S., Gehrig, S., Siebenmann, C., Flück, D., Kirk, N., Hilty, M. P., & Lundby, C. (2016). Twenty-eight days of exposure to 3454 m increases mitochondrial volume density in human skeletal muscle. Journal of Physiology, 594, 1151–1166. https://doi.org/10.1113/JP271118

Abstract

KEY POINTS: It is generally accepted that mitochondrial volume density in human skeletal muscle diminishes with chronic high altitude exposure. All data supporting this concept were collected during mountaineering expeditions, which are associated with the confounding effects of whole body negative energy balance. Here we examine the effect of 28 days of exposure to 3454 m on skeletal muscle mitochondrial volume density in a setting where whole body weight, whole body composition, leg lean mass, skeletal muscle fibre area and maximal