Different regulation of adult hippocampal neurogenesis in Western house mice (Mus musculus domesticus) and C57BL/6 mice

Klaus, F; Hauser, T; Lindholm, A K; Cameron, H A; Slomianka, L; Lipp, H P; Amrein, I

doi:10.1016/j.bbr.2011.07.026

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Klaus, F., Hauser, T., Lindholm, A. K., Cameron, H. A., Slomianka, L., Lipp, H. P., & Amrein, I. (2012). Different regulation of adult hippocampal neurogenesis in Western house mice (Mus musculus domesticus) and C57BL/6 mice. Behavioural Brain Research, 227(2), 340–347. https://doi.org/10.1016/j.bbr.2011.07.026

Abstract

Adult hippocampal neurogenesis (AHN) of laboratory rodents is enhanced by physical exercise in a running wheel. However, little is known about modulation of AHN in wild-living rodent species. The finding that AHN cannot be modulated by voluntary exercise in wild wood mice suggests that AHN may be regulated differently under natural conditions than in laboratory adapted animals. In order to minimize genetic influences, we aimed to investigate the genetically closest wild-living relatives of laboratory mice. Here, C57BL/6 mice and F1 of