Publication: Successful Induction of Specific Immunological Tolerance by Combined Kidney and Hematopoietic Stem Cell Transplantation in HLA-Identical Siblings
Successful Induction of Specific Immunological Tolerance by Combined Kidney and Hematopoietic Stem Cell Transplantation in HLA-Identical Siblings
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Fehr, T., Hübel, K., de Rougemont, O., Abela, I., Gaspert, A., Güngör, T., Hauri, M., Helmchen, B., Linsenmeier, C., Müller, T., Nilsson, J., Riesterer, O., Scandling, J. D., Schanz, U., & Cippà, P. E. (2022). Successful Induction of Specific Immunological Tolerance by Combined Kidney and Hematopoietic Stem Cell Transplantation in HLA-Identical Siblings. Frontiers in Immunology, 13, 796456. https://doi.org/10.3389/fimmu.2022.796456
Abstract
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Abstract
Induction of immunological tolerance has been the holy grail of transplantation immunology for decades. The only successful approach to achieve it in patients has been a combined kidney and hematopoietic stem cell transplantation from an HLA-matched or -mismatched living donor. Here, we report the first three patients in Europe included in a clinical trial aiming at the induction of tolerance by mixed lymphohematopoietic chimerism after kidney transplantation. Two female and one male patient were transplanted with a kidney and periphe
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Creators (Authors)
- Fehr, Thomas
- Hübel, Kerstin
- de Rougemont, Olivier
- Abela, Irene
- Gaspert, Ariana
- Hauri, Mathias
- Helmchen, Birgit
- Linsenmeier, Claudia
- Nilsson, Jakob
- Riesterer, Oliver
- Scandling, John D
- Schanz, Urs
- Cippà, Pietro E
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Fehr, T., Hübel, K., de Rougemont, O., Abela, I., Gaspert, A., Güngör, T., Hauri, M., Helmchen, B., Linsenmeier, C., Müller, T., Nilsson, J., Riesterer, O., Scandling, J. D., Schanz, U., & Cippà, P. E. (2022). Successful Induction of Specific Immunological Tolerance by Combined Kidney and Hematopoietic Stem Cell Transplantation in HLA-Identical Siblings. Frontiers in Immunology, 13, 796456. https://doi.org/10.3389/fimmu.2022.796456
