Closed-Loop Versus Conventional Mechanical Ventilation in COVID-19 ARDS

Wendel Garcia, Pedro David; Hofmaenner, Daniel Andrea; Brugger, Silvio D; Acevedo, Claudio Tirso; Bartussek, Jan; Camen, Giovanni; Bader, Patrick Raphael; Bruellmann, Gregor; Kattner, Johannes; Ganter, Christoph; Schuepbach, Reto Andreas; Buehler, Philipp Karl

doi:10.1177/08850666211024139

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Wendel Garcia, P. D., Hofmaenner, D. A., Brugger, S. D., Acevedo, C. T., Bartussek, J., Camen, G., Bader, P. R., Bruellmann, G., Kattner, J., Ganter, C., Schuepbach, R. A., & Buehler, P. K. (2021). Closed-Loop Versus Conventional Mechanical Ventilation in COVID-19 ARDS. Journal of Intensive Care Medicine, 36(10), 1184–1193. https://doi.org/10.1177/08850666211024139

Abstract

BACKGROUND: Lung-protective ventilation is key in bridging patients suffering from COVID-19 acute respiratory distress syndrome (ARDS) to recovery. However, resource and personnel limitations during pandemics complicate the implementation of lung-protective protocols. Automated ventilation modes may prove decisive in these settings enabling higher degrees of lung-protective ventilation than conventional modes. METHOD: Prospective study at a Swiss university hospital. Critically ill, mechanically ventilated COVID-19 ARDS patients were