Publication: Hierarchical imaging and computational analysis of three-dimensional vascular network architecture in the entire postnatal and adult mouse brain
Hierarchical imaging and computational analysis of three-dimensional vascular network architecture in the entire postnatal and adult mouse brain
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Wälchli, T., Bisschop, J., Miettinen, A., Ulmann-Schuler, A., Hintermüller, C., Meyer, E. P., Krucker, T., Wälchli, R., Monnier, P. P., Carmeliet, P., Vogel, J., & Stampanoni, M. (2021). Hierarchical imaging and computational analysis of three-dimensional vascular network architecture in the entire postnatal and adult mouse brain. Nature Protocols, 16(10), 4564–4610. https://doi.org/10.1038/s41596-021-00587-1
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The formation of new blood vessels and the establishment of vascular networks are crucial during brain development, in the adult healthy brain, as well as in various diseases of the central nervous system. Here, we describe a step-by-step protocol for our recently developed method that enables hierarchical imaging and computational analysis of vascular networks in postnatal and adult mouse brains. The different stages of the procedure include resin-based vascular corrosion casting, scanning electron microscopy, synchrotron radiation a
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- Wälchli, Thomas
- Bisschop, Jeroen
- Miettinen, Arttu
- Ulmann-Schuler, Alexandra
- Hintermüller, Christoph
- Meyer, Eric P
- Krucker, Thomas
- Wälchli, Regula
- Monnier, Philippe P
- Carmeliet, Peter
- Vogel, Johannes
- Stampanoni, Marco
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Wälchli, T., Bisschop, J., Miettinen, A., Ulmann-Schuler, A., Hintermüller, C., Meyer, E. P., Krucker, T., Wälchli, R., Monnier, P. P., Carmeliet, P., Vogel, J., & Stampanoni, M. (2021). Hierarchical imaging and computational analysis of three-dimensional vascular network architecture in the entire postnatal and adult mouse brain. Nature Protocols, 16(10), 4564–4610. https://doi.org/10.1038/s41596-021-00587-1