Publication: Prevalence of HIV-1 drug resistance mutations in proviral DNA in the Swiss HIV Cohort Study, a retrospective study from 1995 to 2018
Prevalence of HIV-1 drug resistance mutations in proviral DNA in the Swiss HIV Cohort Study, a retrospective study from 1995 to 2018
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Jaha, B., Schenkel, C. D., Jörimann, L., Huber, M., Zaheri, M., Neumann, K., Leemann, C., Calmy, A., Cavassini, M., Kouyos, R. D., Günthard, H. F., Metzner, K. J., & Swiss HIV Cohort Study. (2023). Prevalence of HIV-1 drug resistance mutations in proviral DNA in the Swiss HIV Cohort Study, a retrospective study from 1995 to 2018. Journal of Antimicrobial Chemotherapy, 78, 2323–2334. https://doi.org/10.1093/jac/dkad240
Abstract
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Abstract
BACKGROUND: Genotypic resistance testing (GRT) is routinely performed upon diagnosis of HIV-1 infection or during virological failure using plasma viral RNA. An alternative source for GRT could be cellular HIV-1 DNA.
OBJECTIVES: A substantial number of participants in the Swiss HIV Cohort Study (SHCS) never received GRT. We applied a method that enables access to the near full-length proviral HIV-1 genome without requiring detectable viraemia.
METHODS: Nine hundred and sixty-two PBMC specimens were received. Our two-step nested PCR
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- Jaha, Bashkim
- Schenkel, Corinne D
- Jörimann, Lisa
- Zaheri, Maryam
- Neumann, Kathrin
- Leemann, Christine
- Calmy, Alexandra
- Cavassini, Matthias
- Kouyos, Roger D
- Günthard, Huldrych F
- Metzner, Karin J
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Jaha, B., Schenkel, C. D., Jörimann, L., Huber, M., Zaheri, M., Neumann, K., Leemann, C., Calmy, A., Cavassini, M., Kouyos, R. D., Günthard, H. F., Metzner, K. J., & Swiss HIV Cohort Study. (2023). Prevalence of HIV-1 drug resistance mutations in proviral DNA in the Swiss HIV Cohort Study, a retrospective study from 1995 to 2018. Journal of Antimicrobial Chemotherapy, 78, 2323–2334. https://doi.org/10.1093/jac/dkad240
