Publication: Functional coupling of duplex translocation to DNA cleavage in a type I restriction enzyme
Functional coupling of duplex translocation to DNA cleavage in a type I restriction enzyme
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Csefalvay, E., Lapkouski, M., Guzanova, A., Csefalvay, L., Baikova, T., Shevelev, I., Bialevich, V., Shamayeva, K., Janscak, P., Kuta Smatanova, I., Panjikar, S., Carey, J., Weiserova, M., & Ettrich, R. (2015). Functional coupling of duplex translocation to DNA cleavage in a type I restriction enzyme. PLoS ONE, 10, e0128700. https://doi.org/10.1371/journal.pone.0128700
Abstract
Abstract
Abstract
Type I restriction-modification enzymes are multifunctional heteromeric complexes with DNA cleavage and ATP-dependent DNA translocation activities located on motor subunit HsdR. Functional coupling of DNA cleavage and translocation is a hallmark of the Type I restriction systems that is consistent with their proposed role in horizontal gene transfer. DNA cleavage occurs at nonspecific sites distant from the cognate recognition sequence, apparently triggered by stalled translocation. The X-ray crystal structure of the complete HsdR sub
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Creators (Authors)
- Csefalvay, Eva
- Lapkouski, Mikalai
- Guzanova, Alena
- Csefalvay, Ladislav
- Baikova, Tatsiana
- Shevelev, Igor
- Bialevich, Vitali
- Shamayeva, Katsiaryna
- Janscak, Pavel
- Kuta Smatanova, Ivana
- Panjikar, Santosh
- Carey, Jannette
- Weiserova, Marie
- Ettrich, Rüdiger
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Citations
Csefalvay, E., Lapkouski, M., Guzanova, A., Csefalvay, L., Baikova, T., Shevelev, I., Bialevich, V., Shamayeva, K., Janscak, P., Kuta Smatanova, I., Panjikar, S., Carey, J., Weiserova, M., & Ettrich, R. (2015). Functional coupling of duplex translocation to DNA cleavage in a type I restriction enzyme. PLoS ONE, 10, e0128700. https://doi.org/10.1371/journal.pone.0128700
