Delivery of BMP-2 by two clinically available apatite materials: In vitro and in vivo comparison

Hänseler, Patrick; Ehrbar, Martin; Kruse, Astrid; Fischer, Eliane; Schibli, Roger; Ghayor, Chafik; Weber, Franz E

doi:10.1002/jbm.a.35211

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Hänseler, P., Ehrbar, M., Kruse, A., Fischer, E., Schibli, R., Ghayor, C., & Weber, F. E. (2015). Delivery of BMP-2 by two clinically available apatite materials: In vitro and in vivo comparison. Journal of Biomedical Materials Research. Part A, 103(2), 628–638. https://doi.org/10.1002/jbm.a.35211

Abstract

Bone morphogenetic proteins (BMPs) are deposited in bone and responsible for osteoinduction. The interplay between delivery system and BMP, resulting in a characteristic release profile, is crucial for clinical success. We here report on two apatite based commercially available granules which could potentially be used in a combination product with recombinant human BMP-2 (rhBMP-2). Regardless of their similar chemistry, their interaction with rhBMP-2 differs. Deproteinized bovine bone matrix (DBBM), a clinically well-established bone