Publication: Axial differences in endocytosis along the kidney proximal tubule
Axial differences in endocytosis along the kidney proximal tubule
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Polesel, M., & Hall, A. M. (2019). Axial differences in endocytosis along the kidney proximal tubule. American Journal of Physiology : Renal Physiology, 317(6), F1526–F1530. https://doi.org/10.1152/ajprenal.00459.2019
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The proximal tubule (PT) reabsorbs filtered proteins via receptor mediated endocytosis to prevent energetically inefficient wasting in the urine. Recent intravital imaging studies have suggested that protein reabsorption occurs in early (S1) segments, which have a very high capacity. In contrast, uptake of fluid phase substrates also occurs in distal (S2) segments. In this article, we will review these findings and their implications for understanding integrated proximal tubular function, patterns of damage caused by endocytosed toxin
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- Polesel, Marcello
- Hall, Andrew M
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Polesel, M., & Hall, A. M. (2019). Axial differences in endocytosis along the kidney proximal tubule. American Journal of Physiology : Renal Physiology, 317(6), F1526–F1530. https://doi.org/10.1152/ajprenal.00459.2019
