Microglial-glucocorticoid receptor depletion alters the response of hippocampal microglia and neurons in a chronic unpredictable mild stress paradigm in female mice

Picard, Katherine; Bisht, Kanchan; Poggini, Silvia; Garofalo, Stefano; Golia, Maria Teresa; Basilico, Bernadette; Abdallah, Fatima; Ciano Albanese, Naomi; Amrein, Irmgard; Vernoux, Nathalie; Sharma, Kaushik; Hui, Chin Wai; Savage, Julie C; Limatola, Cristina; Ragozzino, Davide; Maggi, Laura; Branchi, Igor; Tremblay, Marie-Ève

doi:10.1016/j.bbi.2021.07.022

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Picard, K., Bisht, K., Poggini, S., Garofalo, S., Golia, M. T., Basilico, B., Abdallah, F., Ciano Albanese, N., Amrein, I., Vernoux, N., Sharma, K., Hui, C. W., Savage, J. C., Limatola, C., Ragozzino, D., Maggi, L., Branchi, I., & Tremblay, M.-È. (2021). Microglial-glucocorticoid receptor depletion alters the response of hippocampal microglia and neurons in a chronic unpredictable mild stress paradigm in female mice. Brain, Behavior, and Immunity, 97, 423–439. https://doi.org/10.1016/j.bbi.2021.07.022

Abstract

Chronic psychological stress is one of the most important triggers and environmental risk factors for neuropsychiatric disorders. Chronic stress can influence all organs via the secretion of stress hormones, including glucocorticoids by the adrenal glands, which coordinate the stress response across the body. In the brain, glucocorticoid receptors (GR) are expressed by various cell types including microglia, which are its resident immune cells regulating stress-induced inflammatory processes. To study the roles of microglial GR under