Publication: 10-day hyperlipidemic clamp in cats: effects on insulin sensitivity, inflammation, and glucose metabolism-related genes
10-day hyperlipidemic clamp in cats: effects on insulin sensitivity, inflammation, and glucose metabolism-related genes
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Zini, E., Osto, M., Konrad, D., Franchini, M., Sieber-Ruckstuhl, N. S., Kaufmann, K., Guscetti, F., Ackermann, M., Lutz, T. A., & Reusch, C. E. (2010). 10-day hyperlipidemic clamp in cats: effects on insulin sensitivity, inflammation, and glucose metabolism-related genes. Hormone and Metabolic Research, 42(5), 340–347. https://doi.org/10.1055/s-0030-1248251
Abstract
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Abstract
Obesity and hyperlipidemia are associated with impaired insulin sensitivity in human type 2 diabetes mellitus, possibly due to activation of a mild inflammatory response. Because obesity-induced insulin resistance predisposes cats to diabetes and because hyperlipidemia is a frequent concurrent finding, excess lipids may also impair insulin sensitivity in cats. Healthy cats (n=6) were infused with lipids (Lipovenoes 10%) for 10 days to clamp blood triglycerides at the approximate concentration of untreated feline diabetes (3-7 mmol/l).
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Creators (Authors)
- Zini, Eric
- Osto, Melania
- Franchini, Marco
- Sieber-Ruckstuhl, Nadja S
- Kaufmann, K
- Guscetti, Franco
- Ackermann, Mathias
- Reusch, Claudia E
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Citations
Zini, E., Osto, M., Konrad, D., Franchini, M., Sieber-Ruckstuhl, N. S., Kaufmann, K., Guscetti, F., Ackermann, M., Lutz, T. A., & Reusch, C. E. (2010). 10-day hyperlipidemic clamp in cats: effects on insulin sensitivity, inflammation, and glucose metabolism-related genes. Hormone and Metabolic Research, 42(5), 340–347. https://doi.org/10.1055/s-0030-1248251
