OGR1 (GPR68) and TDAG8 (GPR65) Have Antagonistic Effects in Models of Colonic Inflammation

Perren, Leonie; Busch, Moana; Schuler, Cordelia; Ruiz, Pedro A; Foti, Federica; Weibel, Nathalie; de Vallière, Cheryl; Morsy, Yasser; Seuwen, Klaus; Hausmann, Martin; Rogler, Gerhard

doi:10.5167/uzh-254253

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Perren, L., Busch, M., Schuler, C., Ruiz, P. A., Foti, F., Weibel, N., de Vallière, C., Morsy, Y., Seuwen, K., Hausmann, M., & Rogler, G. (2023). OGR1 (GPR68) and TDAG8 (GPR65) Have Antagonistic Effects in Models of Colonic Inflammation. International Journal of Molecular Sciences, 24, 14855. https://doi.org/10.3390/ijms241914855

Abstract

G-protein-coupled receptors (GPRs), including pro-inflammatory ovarian cancer GPR1 (OGR1/GPR68) and anti-inflammatory T cell death-associated gene 8 (TDAG8/GPR65), are involved in pH sensing and linked to inflammatory bowel disease (IBD). OGR1 and TDAG8 show opposite effects. To determine which effect is predominant or physiologically more relevant, we deleted both receptors in models of intestinal inflammation. Combined Ogr1 and Tdag8 deficiency was assessed in spontaneous and acute murine colitis models. Disease severity was assesse