Publication: Gray matter gamma‐hydroxy‐butyric acid and glutamate reflect beta‐amyloid burden at old age
Gray matter gamma‐hydroxy‐butyric acid and glutamate reflect beta‐amyloid burden at old age
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Schreiner, S. J., Van Bergen, J. M. G., Gietl, A. F., Buck, A., Hock, C., Pruessmann, K. P., Henning, A., & Unschuld, P. G. (2024). Gray matter gamma‐hydroxy‐butyric acid and glutamate reflect beta‐amyloid burden at old age. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 16, e12587. https://doi.org/10.1002/dad2.12587
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Abstract
Gamma‐hydroxy‐butyric acid (GABA) and glutamate are neurotransmitters with essential importance for cognitive processing. Here, we investigate relationships between GABA, glutamate, and brain ß‐amyloid (Aß) burden before clinical manifestation of Alzheimer's disease (AD). Thirty cognitively healthy adults (age 69.9 ± 6 years) received high‐resolution atlas‐based $^{1}$H‐magnetic resonance spectroscopic imaging (MRSI) at ultra‐high magnetic field strength of 7 Tesla for gray matter‐specific assessment of GABA and glutamate. We assessed
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- Van Bergen, Jiri M G
- Gietl, Anton F
- Buck, Alfred
- Hock, Christoph
- Pruessmann, Klaas P
- Henning, Anke
- Unschuld, Paul G
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Schreiner, S. J., Van Bergen, J. M. G., Gietl, A. F., Buck, A., Hock, C., Pruessmann, K. P., Henning, A., & Unschuld, P. G. (2024). Gray matter gamma‐hydroxy‐butyric acid and glutamate reflect beta‐amyloid burden at old age. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 16, e12587. https://doi.org/10.1002/dad2.12587
