Publication: Investigation of the pentathiepin functionality as an inhibitor of Feline Immunodeficiency Virus (FIV) via a potential zinc ejection mechanism, as a model for HIV infection
Investigation of the pentathiepin functionality as an inhibitor of Feline Immunodeficiency Virus (FIV) via a potential zinc ejection mechanism, as a model for HIV infection
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Asquith, C. R. M., Laitinen, T., Konstantinova, L. S., Tizzard, G., Poso, A., Rakitin, O. A., Hofmann-Lehmann, R., & Hilton, S. T. (2019). Investigation of the pentathiepin functionality as an inhibitor of Feline Immunodeficiency Virus (FIV) via a potential zinc ejection mechanism, as a model for HIV infection. ChemMedChem, 14(4), 454–461. https://doi.org/10.1002/cmdc.201800718
Abstract
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Abstract
A small diverse library of pentathiepin derivatives were prepared to evaluate their efficacy against the nucleocapsid protein function of the feline immunodeficiency virus (FIV) as a model for HIV, using an in vitro cell culture approach. This study led to the development of nanomolar active compounds with low toxicity.
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- Asquith, Christopher R M
- Laitinen, Tuomo
- Konstantinova, Lidia S
- Tizzard, Graham
- Poso, Antti
- Rakitin, Oleg A
- Hilton, Stephen T
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Asquith, C. R. M., Laitinen, T., Konstantinova, L. S., Tizzard, G., Poso, A., Rakitin, O. A., Hofmann-Lehmann, R., & Hilton, S. T. (2019). Investigation of the pentathiepin functionality as an inhibitor of Feline Immunodeficiency Virus (FIV) via a potential zinc ejection mechanism, as a model for HIV infection. ChemMedChem, 14(4), 454–461. https://doi.org/10.1002/cmdc.201800718
