Publication: The HeMoVal study protocol: a prospective international multicenter cohort study to validate cerebrospinal fluid hemoglobin as a monitoring biomarker for aneurysmal subarachnoid hemorrhage related secondary brain injury
The HeMoVal study protocol: a prospective international multicenter cohort study to validate cerebrospinal fluid hemoglobin as a monitoring biomarker for aneurysmal subarachnoid hemorrhage related secondary brain injury
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Akeret, K., Buzzi, R. M., Saxenhofer, M., Bieri, K., Chiavi, D., Thomson, B. R., Grüttner-Durmaz, M., Schwendinger, N., Humar, R., Regli, L., van Doormaal, T. P. C., Held, U., Keller, E., Hugelshofer, M., Schaer, D. J., & et al. (2022). The HeMoVal study protocol: a prospective international multicenter cohort study to validate cerebrospinal fluid hemoglobin as a monitoring biomarker for aneurysmal subarachnoid hemorrhage related secondary brain injury. BMC Neurology, 22, 267. https://doi.org/10.1186/s12883-022-02789-w
Abstract
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Abstract
Introduction: Preclinical studies provided a strong rationale for a pathophysiological link between cell-free hemoglobin in the cerebrospinal fluid (CSF-Hb) and secondary brain injury after subarachnoid hemorrhage (SAH-SBI). In a single-center prospective observational clinical study, external ventricular drain (EVD) based CSF-Hb proved to be a promising biomarker to monitor for SAH-SBI. The primary objective of the HeMoVal study is to prospectively validate the association between EVD based CSF-Hb and SAH-SBI during the first 14 days
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- Akeret, Kevin
- Saxenhofer, Moritz
- Bieri, Kathrin
- Chiavi, Deborah
- Thomson, Bart R
- Grüttner-Durmaz, Manuela
- Schwendinger, Nina
- Humar, Rok
- Regli, Luca
- van Doormaal, Tristan P C
- Held, Ulrike
- Hugelshofer, Michael
- Schaer, Dominik J
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Akeret, K., Buzzi, R. M., Saxenhofer, M., Bieri, K., Chiavi, D., Thomson, B. R., Grüttner-Durmaz, M., Schwendinger, N., Humar, R., Regli, L., van Doormaal, T. P. C., Held, U., Keller, E., Hugelshofer, M., Schaer, D. J., & et al. (2022). The HeMoVal study protocol: a prospective international multicenter cohort study to validate cerebrospinal fluid hemoglobin as a monitoring biomarker for aneurysmal subarachnoid hemorrhage related secondary brain injury. BMC Neurology, 22, 267. https://doi.org/10.1186/s12883-022-02789-w
