Publication: Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of rapamycin interaction proteome.
Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of rapamycin interaction proteome.
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Glatter, T., Schittenhelm, R. B., Rinner, O., Roguska, K., Wepf, A., Jünger, M. A., Köhler, K., Jevtov, I., Choi, H., Schmidt, A., Nesvizhskii, A. I., Stocker, H., Hafen, E., Aebersold, R., & Gstaiger, M. (2011). Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of rapamycin interaction proteome. Molecular Systems Biology, 7, 547. https://doi.org/10.1038/msb.2011.79
Abstract
Abstract
Abstract
Genetic analysis in Drosophila melanogaster has been widely used to identify a system of genes that control cell growth in response to insulin and nutrients. Many of these genes encode components of the insulin receptor/target of rapamycin (InR/TOR) pathway. However, the biochemical context of this regulatory system is still poorly characterized in Drosophila. Here, we present the first quantitative study that systematically characterizes the modularity and hormone sensitivity of the interaction proteome underlying growth control by t
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Creators (Authors)
- Glatter, Timo
- Schittenhelm, Ralf B
- Rinner, Oliver
- Roguska, Katarzyna
- Wepf, Alexander
- Jünger, Martin A
- Köhler, Katja
- Jevtov, Irena
- Choi, Hyungwon
- Schmidt, Alexander
- Nesvizhskii, Alexey I
- Stocker, Hugo
- Hafen, Ernst
- Aebersold, Ruedi
- Gstaiger, Matthias
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Citations
Glatter, T., Schittenhelm, R. B., Rinner, O., Roguska, K., Wepf, A., Jünger, M. A., Köhler, K., Jevtov, I., Choi, H., Schmidt, A., Nesvizhskii, A. I., Stocker, H., Hafen, E., Aebersold, R., & Gstaiger, M. (2011). Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of rapamycin interaction proteome. Molecular Systems Biology, 7, 547. https://doi.org/10.1038/msb.2011.79
