Publication: Sevoflurane Protects Hepatocytes From Ischemic Injury by Reducing Reactive Oxygen Species Signaling of Hepatic Stellate Cells: Translational Findings Based on a Clinical Trial
Sevoflurane Protects Hepatocytes From Ischemic Injury by Reducing Reactive Oxygen Species Signaling of Hepatic Stellate Cells: Translational Findings Based on a Clinical Trial
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Beck-Schimmer, B., Roth Z’graggen, B., Booy, C., Köppel, S., Spahn, D. R., Schläpfer, M., & Schadde, E. (2018). Sevoflurane Protects Hepatocytes From Ischemic Injury by Reducing Reactive Oxygen Species Signaling of Hepatic Stellate Cells: Translational Findings Based on a Clinical Trial. Anesthesia and Analgesia, 127(4), 1058–1065. https://doi.org/10.1213/ANE.0000000000003692
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BACKGROUND Randomized controlled trials (RCTs) data demonstrate that sevoflurane postconditioning improves clinical outcomes of liver resection with inflow occlusion, presumably due to hepatocyte protection from ischemic injury. However, mechanisms remain unclear. This study examines liver biopsy samples obtained in an RCT of sevoflurane postconditioning to test the hypothesis that sevoflurane attenuates hepatocyte apoptosis. METHODS Messenger ribonucleic acid (mRNA) of pro- and antiapoptotic regulators Bax and B-cell lymphoma 2 (B
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- Beck-Schimmer, Beatrice
- Roth Z'graggen, Birgit
- Booy, Christa
- Köppel, Sabrina
- Spahn, Donat R
- Schläpfer, Martin
- Schadde, Erik
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Beck-Schimmer, B., Roth Z’graggen, B., Booy, C., Köppel, S., Spahn, D. R., Schläpfer, M., & Schadde, E. (2018). Sevoflurane Protects Hepatocytes From Ischemic Injury by Reducing Reactive Oxygen Species Signaling of Hepatic Stellate Cells: Translational Findings Based on a Clinical Trial. Anesthesia and Analgesia, 127(4), 1058–1065. https://doi.org/10.1213/ANE.0000000000003692
