Publication: Non-redundant roles of the CCR1 and CCR2 chemokine axes in monocyte recruitment during lung metastasis
Non-redundant roles of the CCR1 and CCR2 chemokine axes in monocyte recruitment during lung metastasis
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Liner, A. G., van Gogh, M., Roblek, M., Heikenwalder, M., & Borsig, L. (2025). Non-redundant roles of the CCR1 and CCR2 chemokine axes in monocyte recruitment during lung metastasis. Neoplasia, 59, 101089. https://doi.org/10.1016/j.neo.2024.101089
Abstract
Abstract
Abstract
Monocytes and monocyte-derived macrophages facilitate cancer progression and metastasis. Inflammatory monocytes expressing CCR2 are actively recruited to metastatic lungs, where they promote tumor cell extravasation, metastatic outgrowth, and an immunosuppressive environment. The role of CCR1 in this process has remained unclear. We used Ccr1- and Ccr2-deficient mice and two different tumor cells lines, MC38 and LLC1 with and without Ccl2-deficiency in vitro and in vivo. The recruitment of both Ccr1- and Ccr2-deficient monocytes towar
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- Liner, Alessia G
- van Gogh, Merel
- Roblek, Marko
- Heikenwalder, Matthias
- Borsig, Lubor
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Liner, A. G., van Gogh, M., Roblek, M., Heikenwalder, M., & Borsig, L. (2025). Non-redundant roles of the CCR1 and CCR2 chemokine axes in monocyte recruitment during lung metastasis. Neoplasia, 59, 101089. https://doi.org/10.1016/j.neo.2024.101089
