Adverse effects of polymyxin B administration to healthy horses

van Spijk, Julia N; Beckmann, Katrin; Wehrli Eser, Meret; Boxler, Martina; Stirn, Martina; Rhyner, Thea; Kaelin, Dana; Saleh, Lanja; Schoster, Angelika

doi:10.5167/uzh-220593

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van Spijk, J. N., Beckmann, K., Wehrli Eser, M., Boxler, M., Stirn, M., Rhyner, T., Kaelin, D., Saleh, L., & Schoster, A. (2022). Adverse effects of polymyxin B administration to healthy horses. Journal of Veterinary Internal Medicine, 36, 1525–1534. https://doi.org/10.1111/jvim.16470

Abstract

Background: Polymyxin B (PolyB) is used to treat endotoxemia in horses; neurologic and nephrogenic adverse effects occur in humans. Objectives: To describe PolyB adverse effects in horses. Animals: Five healthy horses (ataxia 0/5), 1 horse with cervical osteoarthritis (ataxia 1/5). Methods: Prospective blinded randomized cross-over trial; 3-weeks wash out. Horses received PolyB (PolyB 6000 IU/kg IV, 7 doses q12h, n = 6) and PolyB/gentamicin (PolyB 6000 IU/kg IV, q12h 7 doses; gentamicin 10 mg/kg IV q24h 4 doses n = 4, or q12-24 h 5 do