Publication: Different Whole-Brain Functional Connectivity Correlates of Reactive-Proactive Aggression and Callous-Unemotional Traits in Children and Adolescents with Disruptive Behaviors
Different Whole-Brain Functional Connectivity Correlates of Reactive-Proactive Aggression and Callous-Unemotional Traits in Children and Adolescents with Disruptive Behaviors
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Werhahn, J. E., Smigielski, L., Sacu, S., Mohl, S., Willinger, D., Naaijen, J., Mulder, L. M., Glennon, J. C., Hoekstra, P. J., Dietrich, A., Deters, R. K., Aggensteiner, P. M., Holz, N. E., Baumeister, S., Banaschewski, T., Saam, M. C., Schulze, U. M. E., Lythgoe, D. J., Sethi, A., … Brandeis, D. (2023). Different Whole-Brain Functional Connectivity Correlates of Reactive-Proactive Aggression and Callous-Unemotional Traits in Children and Adolescents with Disruptive Behaviors. NeuroImage. Clinical, 40, 103542. https://doi.org/10.1016/j.nicl.2023.103542
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Background: Disruptive behavior in children and adolescents can manifest as reactive aggression and proactive aggression and is modulated by callous-unemotional traits and other comorbidities. Neural correlates of these aggression dimensions or subtypes and comorbid symptoms remain largely unknown. This multi-center study investigated the relationship between resting state functional connectivity (rsFC) and aggression subtypes considering comorbidities.
Methods: The large sample of children and adolescents aged 8–18 years (n = 207; m
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Werhahn, J. E., Smigielski, L., Sacu, S., Mohl, S., Willinger, D., Naaijen, J., Mulder, L. M., Glennon, J. C., Hoekstra, P. J., Dietrich, A., Deters, R. K., Aggensteiner, P. M., Holz, N. E., Baumeister, S., Banaschewski, T., Saam, M. C., Schulze, U. M. E., Lythgoe, D. J., Sethi, A., … Brandeis, D. (2023). Different Whole-Brain Functional Connectivity Correlates of Reactive-Proactive Aggression and Callous-Unemotional Traits in Children and Adolescents with Disruptive Behaviors. NeuroImage. Clinical, 40, 103542. https://doi.org/10.1016/j.nicl.2023.103542
