Unraveling the Function of PARP1 in Natural Killer Cell-Regulated Immune Signaling: PARP1 Mediates Cytokine Dependent T Cell Polarization and T Cell Tumor Infiltration

Abstract

A major challenge for both the immune system as well as anti-tumor drugs is the specific killing of tumor cells. The challenge lies in distinguishing “dangerous self” cells from “non-dangerous self” cells. One sophisticated approach to specifically kill tumor cells is to exploit synthetic lethal interactions as demonstrated by PARP inhibitors. These inhibitors target PARP1, a ubiquitous protein that is crucial for the early detection of DNA damage through ADP-ribosylation of target proteins and specifically induce tumor cell death in Show more