Publication: Unsilencing of native leptin receptors (LepR) in hypothalamic SF1 neurons does not rescue obese phenotype in LepR-deficient mice
Unsilencing of native leptin receptors (LepR) in hypothalamic SF1 neurons does not rescue obese phenotype in LepR-deficient mice
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Senn, S. S., Le Foll, C., Whiting, L., Tarasco, E., Duffy, S., Lutz, T. A., & Boyle, C. N. (2019). Unsilencing of native leptin receptors (LepR) in hypothalamic SF1 neurons does not rescue obese phenotype in LepR-deficient mice. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 317(3), R451–R460. https://doi.org/10.1152/ajpregu.00111.2019
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Leptin receptor (LepR) signaling in neurons of the ventromedial nucleus of the hypothalamus (VMH), specifically those expressing steroidogenic factor-1 (SF1), have been proposed to play a key role in controlling energy balance. By crossing LepR-silenced (LepR) mice to those expressing SF1-Cre, we unsilenced native LepR specifically in the VMH and tested whether SF1 neurons in the VMH are critical mediators of leptin's effect on energy homeostasis. LepR x SF1-Cre (KO/Tg+) mice were metabolically phenotyped and compared to littermate co
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- Senn, Seraina S
- Whiting, Lynda
- Tarasco, Erika
- Duffy, Sonya
- Boyle, Christina Neuner
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Senn, S. S., Le Foll, C., Whiting, L., Tarasco, E., Duffy, S., Lutz, T. A., & Boyle, C. N. (2019). Unsilencing of native leptin receptors (LepR) in hypothalamic SF1 neurons does not rescue obese phenotype in LepR-deficient mice. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 317(3), R451–R460. https://doi.org/10.1152/ajpregu.00111.2019
