Publication: DEPDC1/LET-99 participates in an evolutionarily conserved pathway for anti-tubulin drug-induced apoptosis
DEPDC1/LET-99 participates in an evolutionarily conserved pathway for anti-tubulin drug-induced apoptosis
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Sendoel, A., Maida, S., Zheng, X., Teo, Y., Stergiou, L., Rossi, C. A., Subasic, D., Pinto, S. M., Kinchen, J. M., Shi, M., Boettcher, S., Meyer, J. N., Manz, M. G., Bano, D., & Hengartner, M. O. (2014). DEPDC1/LET-99 participates in an evolutionarily conserved pathway for anti-tubulin drug-induced apoptosis. Nature Cell Biology, 16(8), 812–820. https://doi.org/10.1038/ncb3010
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Abstract
Microtubule-targeting chemotherapeutics induce apoptosis in cancer cells by promoting the phosphorylation and degradation of the anti-apoptotic BCL-2 family member MCL1. The signalling cascade linking microtubule disruption to MCL1 degradation remains however to be defined. Here, we establish an in vivo screening strategy in Caenorhabditis elegans to uncover genes involved in chemotherapy-induced apoptosis. Using an RNAi-based screen, we identify three genes required for vincristine-induced apoptosis. We show that the DEP domain prote
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- Sendoel, A
- Maida, S
- Zheng, X
- Teo, Y
- Stergiou, L
- Rossi, C A
- Subasic, D
- Pinto, S M
- Kinchen, J M
- Shi, M
- Boettcher, S
- Meyer, J N
- Manz, M G
- Bano, D
- Hengartner, M O
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Sendoel, A., Maida, S., Zheng, X., Teo, Y., Stergiou, L., Rossi, C. A., Subasic, D., Pinto, S. M., Kinchen, J. M., Shi, M., Boettcher, S., Meyer, J. N., Manz, M. G., Bano, D., & Hengartner, M. O. (2014). DEPDC1/LET-99 participates in an evolutionarily conserved pathway for anti-tubulin drug-induced apoptosis. Nature Cell Biology, 16(8), 812–820. https://doi.org/10.1038/ncb3010