Publication: Targeted anatomical and functional identification of antinociceptive and pronociceptive serotonergic neurons that project to the spinal dorsal horn
Targeted anatomical and functional identification of antinociceptive and pronociceptive serotonergic neurons that project to the spinal dorsal horn
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Ganley, R. P., de Sousa, M. M., Werder, K., Öztürk, T., Mendes, R., Ranucci, M., Wildner, H., & Zeilhofer, H. U. (2023). Targeted anatomical and functional identification of antinociceptive and pronociceptive serotonergic neurons that project to the spinal dorsal horn. ELife, 12, e78689. https://doi.org/10.7554/eLife.78689
Abstract
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Abstract
Spinally projecting serotonergic neurons play a key role in controlling pain sensitivity and can either increase or decrease nociception depending on physiological context. It is currently unknown how serotonergic neurons mediate these opposing effects. Utilizing virus-based strategies and Tph2-Cre transgenic mice, we identified two anatomically separated populations of serotonergic hindbrain neurons located in the lateral paragigantocellularis (LPGi) and the medial hindbrain, which respectively innervate the superficial and deep spin
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- Ganley, Robert Philip
- de Sousa, Marilia Magalhaes
- Werder, Kira
- Öztürk, Tugce
- Mendes, Raquel
- Ranucci, Matteo
- Wildner, Hendrik
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Ganley, R. P., de Sousa, M. M., Werder, K., Öztürk, T., Mendes, R., Ranucci, M., Wildner, H., & Zeilhofer, H. U. (2023). Targeted anatomical and functional identification of antinociceptive and pronociceptive serotonergic neurons that project to the spinal dorsal horn. ELife, 12, e78689. https://doi.org/10.7554/eLife.78689
