Publication: Multi-region proteome analysis quantifies spatial heterogeneity of prostate tissue biomarkers
Multi-region proteome analysis quantifies spatial heterogeneity of prostate tissue biomarkers
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Guo, T., Li, L., Zhong, Q., Rupp, N. J., Charmpi, K., Wong, C. E., Wagner, U., Rueschoff, J. H., Jochum, W., Fankhauser, C. D., Saba, K., Poyet, C., Wild, P. J., Aebersold, R., & Beyer, A. (2018). Multi-region proteome analysis quantifies spatial heterogeneity of prostate tissue biomarkers. Life Science Alliance, 1(2), e201800042. https://doi.org/10.26508/lsa.201800042
Abstract
Abstract
Abstract
It remains unclear to what extent tumor heterogeneity impacts on protein biomarker discovery. Here, we quantified proteome intra-tissue heterogeneity (ITH) based on a multi-region analysis of prostate tissues using pressure cycling technology and Sequential Windowed Acquisition of all THeoretical fragment ion mass spectrometry. We quantified 6,873 proteins and analyzed the ITH of 3,700 proteins. The level of ITH varied depending on proteins and tissue types. Benign tissues exhibited more complex ITH patterns than malignant tissues. Sp
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Creators (Authors)
- Guo, Tiannan
- Li, Li
- Zhong, Qing
- Rupp, Niels J
- Charmpi, Konstantina
- Wong, Christine E
- Wagner, Ulrich
- Rueschoff, Jan H
- Jochum, Wolfram
- Fankhauser, Christian Daniel
- Saba, Karim
- Poyet, Cedric
- Wild, Peter J
- Aebersold, Ruedi
- Beyer, Andreas
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Citations
Guo, T., Li, L., Zhong, Q., Rupp, N. J., Charmpi, K., Wong, C. E., Wagner, U., Rueschoff, J. H., Jochum, W., Fankhauser, C. D., Saba, K., Poyet, C., Wild, P. J., Aebersold, R., & Beyer, A. (2018). Multi-region proteome analysis quantifies spatial heterogeneity of prostate tissue biomarkers. Life Science Alliance, 1(2), e201800042. https://doi.org/10.26508/lsa.201800042
