Publication: Delineating CD4 dependency of HIV-1: Adaptation to infect low level CD4 expressing target cells widens cellular tropism but severely impacts on envelope functionality
Delineating CD4 dependency of HIV-1: Adaptation to infect low level CD4 expressing target cells widens cellular tropism but severely impacts on envelope functionality
Date
Date
Date
Citations
Beauparlant, D., Rusert, P., Magnus, C., Kadelka, C., Weber, J., Uhr, T., Zagordi, O., Oberle, C., Duenas-Decamp, M. J., Clapham, P. R., Metzner, K. J., Günthard, H. F., & Trkola, A. (2017). Delineating CD4 dependency of HIV-1: Adaptation to infect low level CD4 expressing target cells widens cellular tropism but severely impacts on envelope functionality. PLoS Pathogens, 13, e1006255. https://doi.org/10.1371/journal.ppat.1006255
Abstract
Abstract
Abstract
A hallmark of HIV-1 infection is the continuously declining number of the virus' predominant target cells, activated CD4+ T cells. With diminishing CD4+ T cell levels, the capacity to utilize alternate cell types and receptors, including cells that express low CD4 receptor levels such as macrophages, thus becomes crucial. To explore evolutionary paths that allow HIV-1 to acquire a wider host cell range by infecting cells with lower CD4 levels, we dissected the evolution of the envelope-CD4 interaction under in vitro culture conditions
Additional indexing
Creators (Authors)
- Beauparlant, David
- Rusert, Peter
- Magnus, Carsten
- Kadelka, Claus
- Weber, Jacqueline
- Uhr, Therese
- Zagordi, Osvaldo
- Oberle, Corinna
- Duenas-Decamp, Maria J
- Clapham, Paul R
- Metzner, Karin J
- Günthard, Huldrych F
Volume
Volume
Volume
Number
Number
Number
Page range/Item number
Page range/Item number
Page range/Item number
Item Type
Item Type
Item Type
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Free Access at
Free Access at
Free Access at
Publisher DOI
Citations
Beauparlant, D., Rusert, P., Magnus, C., Kadelka, C., Weber, J., Uhr, T., Zagordi, O., Oberle, C., Duenas-Decamp, M. J., Clapham, P. R., Metzner, K. J., Günthard, H. F., & Trkola, A. (2017). Delineating CD4 dependency of HIV-1: Adaptation to infect low level CD4 expressing target cells widens cellular tropism but severely impacts on envelope functionality. PLoS Pathogens, 13, e1006255. https://doi.org/10.1371/journal.ppat.1006255
