Publication: Single-cell profiling of myasthenia gravis identifies a pathogenic T cell signature
Single-cell profiling of myasthenia gravis identifies a pathogenic T cell signature
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Ingelfinger, F., Krishnarajah, S., Kramer, M., Utz, S. G., Galli, E., Lutz, M., Zwicky, P., Akarca, A. U., Jurado, N. P., Ulutekin, C., Bamert, D., Widmer, C. C., Piccoli, L., Sallusto, F., Núñez, N. G., Marafioti, T., Schneiter, D., Opitz, I., Lanzavecchia, A., … Becher, B. (2021). Single-cell profiling of myasthenia gravis identifies a pathogenic T cell signature. Acta Neuropathologica, 141(6), 901–915. https://doi.org/10.1007/s00401-021-02299-y
Abstract
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Abstract
Myasthenia gravis (MG) is an autoimmune disease characterized by impaired neuromuscular signaling due to autoantibodies targeting the acetylcholine receptor. Although its auto-antigens and effector mechanisms are well defined, the cellular and molecular drivers underpinning MG remain elusive. Here, we employed high-dimensional single-cell mass and spectral cytometry of blood and thymus samples from MG patients in combination with supervised and unsupervised machine-learning tools to gain insight into the immune dysregulation underlyin
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Creators (Authors)
- Ingelfinger, Florian
- Krishnarajah, Sinduya
- Kramer, Michael
- Utz, Sebastian G
- Galli, Edoardo
- Lutz, Mirjam
- Zwicky, Pascale
- Akarca, Ayse U
- Jurado, Nicole Puertas
- Ulutekin, Can
- Bamert, David
- Widmer, Corinne C
- Piccoli, Luca
- Sallusto, Federica
- Núñez, Nicolás Gonzalo
- Marafioti, Teresa
- Schneiter, Didier
- Opitz, Isabelle
- Lanzavecchia, Antonio
- Jung, Hans H
- De Feo, Donatella
- Mundt, Sarah
- Schreiner, Bettina
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Citations
Ingelfinger, F., Krishnarajah, S., Kramer, M., Utz, S. G., Galli, E., Lutz, M., Zwicky, P., Akarca, A. U., Jurado, N. P., Ulutekin, C., Bamert, D., Widmer, C. C., Piccoli, L., Sallusto, F., Núñez, N. G., Marafioti, T., Schneiter, D., Opitz, I., Lanzavecchia, A., … Becher, B. (2021). Single-cell profiling of myasthenia gravis identifies a pathogenic T cell signature. Acta Neuropathologica, 141(6), 901–915. https://doi.org/10.1007/s00401-021-02299-y
