Publication: Microbial energy metabolism fuels an intestinal macrophage niche in solitary isolated lymphoid tissues through purinergic signaling
Microbial energy metabolism fuels an intestinal macrophage niche in solitary isolated lymphoid tissues through purinergic signaling
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Chiaranunt, P., Burrows, K., Ngai, L., Tai, S. L., Cao, E. Y., Liang, H., Hamidzada, H., Wong, A., Gschwend, J., Flüchter, P., Kuypers, M., Despot, T., Momen, A., Lim, S. M., Mallevaey, T., Schneider, C., Conway, T., Imamura, H., Epelman, S., & Mortha, A. (2023). Microbial energy metabolism fuels an intestinal macrophage niche in solitary isolated lymphoid tissues through purinergic signaling. Science Immunology, 8(86), eabq4573. https://doi.org/10.1126/sciimmunol.abq4573
Abstract
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Abstract
Maintaining macrophage (MΦ) heterogeneity is critical to ensure intestinal tissue homeostasis and host defense. The gut microbiota and host factors are thought to synergistically guide intestinal MΦ development, although the exact nature, regulation, and location of such collaboration remain unclear. Here, we report that microbial biochemical energy metabolism promotes colony-stimulating factor 2 (CSF2) production by group 3 innate lymphoid cells (ILC3s) within solitary isolated lymphoid tissues (SILTs) in a cell-extrinsic, NLRP3/P2X7
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Creators (Authors)
- Chiaranunt, Pailin
- Burrows, Kyle
- Ngai, Louis
- Tai, Siu Ling
- Cao, Eric Y
- Liang, Helen
- Hamidzada, Homaira
- Wong, Anthony
- Gschwend, Julia
- Flüchter, Pascal
- Kuypers, Meggie
- Despot, Tijana
- Momen, Abdul
- Lim, Sung Min
- Mallevaey, Thierry
- Conway, Tyrrell
- Imamura, Hiromi
- Epelman, Slava
- Mortha, Arthur
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Chiaranunt, P., Burrows, K., Ngai, L., Tai, S. L., Cao, E. Y., Liang, H., Hamidzada, H., Wong, A., Gschwend, J., Flüchter, P., Kuypers, M., Despot, T., Momen, A., Lim, S. M., Mallevaey, T., Schneider, C., Conway, T., Imamura, H., Epelman, S., & Mortha, A. (2023). Microbial energy metabolism fuels an intestinal macrophage niche in solitary isolated lymphoid tissues through purinergic signaling. Science Immunology, 8(86), eabq4573. https://doi.org/10.1126/sciimmunol.abq4573
