Publication: Mammalian metallothionein-3: new functional and structural insights
Mammalian metallothionein-3: new functional and structural insights
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Vašák, M., & Meloni, G. (2017). Mammalian metallothionein-3: new functional and structural insights. International Journal of Molecular Sciences, 18(6), 1117. https://doi.org/10.3390/ijms18061117
Abstract
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Abstract
Metallothionein-3 (MT-3), a member of the mammalian metallothionein (MT) family, is mainly expressed in the central nervous system (CNS). MT-3 possesses a unique neuronal growth inhibitory activity, and the levels of this intra- and extracellularly occurring metalloprotein are markedly diminished in the brain of patients affected by a number of metal-linked neurodegenerative disorders, including Alzheimer's disease (AD). In these pathologies, the redox cycling of copper, accompanied by the production of reactive oxygen species (ROS),
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- Vašák, Milan
- Meloni, Gabriele
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Citations
Vašák, M., & Meloni, G. (2017). Mammalian metallothionein-3: new functional and structural insights. International Journal of Molecular Sciences, 18(6), 1117. https://doi.org/10.3390/ijms18061117
