Publication: Apolipoprotein M modulates erythrocyte efflux and tubular reabsorption of sphingosine-1-phosphate
Apolipoprotein M modulates erythrocyte efflux and tubular reabsorption of sphingosine-1-phosphate
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Sutter, I., Park, R., Othman, A., Rohrer, L., Hornemann, T., Stoffel, M., Devuyst, O., & von Eckardstein, A. (2014). Apolipoprotein M modulates erythrocyte efflux and tubular reabsorption of sphingosine-1-phosphate. Journal of Lipid Research, 55(8), 1730–1737. https://doi.org/10.1194/jlr.M050021
Abstract
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Abstract
Sphingosine-1-phosphate (S1P) mediates several cytoprotective functions of HDL. ApoM acts as an S1P binding protein in HDL. Erythrocytes are the major source of S1P in plasma. After glomerular filtration apoM is endocytosed in the proximal renal tubules. Human or murine HDL elicited time- and dose-dependent S1P efflux from erythrocytes. Compared to HDL of wild type (wt) mice, S1P efflux was enhanced in the presence of HDL from apoM transgenic mice but not diminished in the presence of HDL from apoM knock-out (Apom-/-) mice. Artificial
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- Sutter, Iryna
- Park, Rebekka
- Othman, Alaa
- Rohrer, Lucia
- Hornemann, Thorsten
- Stoffel, Markus
- Devuyst, Olivier
- von Eckardstein, Arnold
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Sutter, I., Park, R., Othman, A., Rohrer, L., Hornemann, T., Stoffel, M., Devuyst, O., & von Eckardstein, A. (2014). Apolipoprotein M modulates erythrocyte efflux and tubular reabsorption of sphingosine-1-phosphate. Journal of Lipid Research, 55(8), 1730–1737. https://doi.org/10.1194/jlr.M050021
