Publication: Erythropoietin receptor regulates tumor mitochondrial biogenesis through iNOS and pAKT
Erythropoietin receptor regulates tumor mitochondrial biogenesis through iNOS and pAKT
Date
Date
Date
Citations
Aboouf, M. A., Guscetti, F., von Büren, N., Armbruster, J., Ademi, H., Ruetten, M., Melendez-Rodríguez, F., Rülicke, T., Seymer, A., Jacobs, R. A., Schneider Gasser, E. M., Aragones, J., Neumann, D., Gassmann, M., & Thiersch, M. (2022). Erythropoietin receptor regulates tumor mitochondrial biogenesis through iNOS and pAKT. Frontiers in Oncology, 12, 976961. https://doi.org/10.3389/fonc.2022.976961
Abstract
Abstract
Abstract
Erythropoietin receptor (EPOR) is widely expressed in healthy and malignant tissues. In certain malignancies, EPOR stimulates tumor growth. In healthy tissues, EPOR controls processes other than erythropoiesis, including mitochondrial metabolism. We hypothesized that EPOR also controls the mitochondrial metabolism in cancer cells. To test this hypothesis, we generated EPOR-knockdown cancer cells to grow tumor xenografts in mice and analyzed tumor cellular respiration via high-resolution respirometry. Furthermore, we analyzed cellular
Metrics
Downloads
Views
Additional indexing
Creators (Authors)
- Guscetti, Franco
- von Büren, Nadine
- Armbruster, Julia
- Ademi, Hyrije
- Ruetten, Maja
- Melendez-Rodríguez, Florinda
- Rülicke, Thomas
- Seymer, Alexander
- Jacobs, Robert A
- Schneider Gasser, Edith M
- Aragones, Julian
- Neumann, Drorit
- Gassmann, Max
- Thiersch, Markus
Volume
Volume
Volume
Page range/Item number
Page range/Item number
Page range/Item number
Item Type
Item Type
Item Type
Keywords
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Free Access at
Free Access at
Free Access at
Publisher DOI
Metrics
Downloads
Views
Citations
Aboouf, M. A., Guscetti, F., von Büren, N., Armbruster, J., Ademi, H., Ruetten, M., Melendez-Rodríguez, F., Rülicke, T., Seymer, A., Jacobs, R. A., Schneider Gasser, E. M., Aragones, J., Neumann, D., Gassmann, M., & Thiersch, M. (2022). Erythropoietin receptor regulates tumor mitochondrial biogenesis through iNOS and pAKT. Frontiers in Oncology, 12, 976961. https://doi.org/10.3389/fonc.2022.976961
