Publication: Evaluation of 5H-Thiazolo[3,2-α]pyrimidin-5-ones as Potential GluN2A PET Tracers
Date
Date
Date
2020
Journal Article
Published version
Abstract
Abstract
Abstract
We describe here our efforts to develop a PET tracer for imaging GluN2A-containing NMDA receptors, based on a 5H-thiazolo[3,2-α]pyrimidin-5-one scaffold. The metabolic stability and overall properties could be optimized satisfactorily, although binding affinities remained a limiting factor for in vivo imaging. We nevertheless identified 7-(((2-fluoroethyl)(3-fluorophenyl)amino)-methyl)-3-(2-(hydroxymethyl)cyclopropyl)-2-methyl-5H-thiazolo-[3,2-α]pyrimidin-5-one ([18 F]7b) as a radioligand providing good-quality images in autoradiograp
Metrics
Views
57 since deposited on 2021-02-25
Acq. date: 2025-11-12
Additional indexing
Creators (Authors)
- He, Yingfang
- Whitehead, David M
- Briard, Emmanuelle
- Numao, Shin
- Mu, Linjing
- Schibli, Roger
- Ametamey, Simon M
- Auberson, Yves P
Volume
Volume
Volume
15
Number
Number
Number
24
Page range/Item number
Page range/Item number
Page range/Item number
2448
Page end
Page end
Page end
2461
Item Type
Item Type
Item Type
Journal Article
In collections
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Language
Language
Language
English
Publication date
Publication date
Publication date
2020-12-15
Date available
Date available
Date available
2021-02-25
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
1860-7179
OA Status
OA Status
OA Status
Closed
Publisher DOI
Metrics
Views
57 since deposited on 2021-02-25
Acq. date: 2025-11-12
Closed
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