Publication: Shaping of signal transmission at the photoreceptor synapse by EAAT2 glutamate transporters
Shaping of signal transmission at the photoreceptor synapse by EAAT2 glutamate transporters
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Niklaus, S., Cadetti, L., Vom Berg-Maurer, C. M., Lehnherr, A., Hotz, A. L., Forster, I. C., Gesemann, M., & Neuhauss, S. C. F. (2017). Shaping of signal transmission at the photoreceptor synapse by EAAT2 glutamate transporters. ENeuro, 4(3), e0339. https://doi.org/10.1523/ENEURO.0339-16.2017
Abstract
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Abstract
Photoreceptor ribbon synapses tonically release glutamate. To ensure efficient signal transmission and prevent glutamate toxicity, a highly efficient glutamate removal system provided by members of the SLC1 gene family is required. By using a combination of biophysical and in vivo studies, we elucidate the role of excitatory amino acid transporter 2 (EAAT2) proteins in synaptic glutamate homeostasis at the zebrafish photoreceptor synapse. The main glutamate sink is provided by the glial EAAT2a, reflected by reduced electroretinographi
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- Niklaus, Stephanie
- Cadetti, Lucia
- Vom Berg-Maurer, Colette M
- Lehnherr, André
- Hotz, Adriana L
- Forster, Ian C
- Gesemann, Matthias
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Niklaus, S., Cadetti, L., Vom Berg-Maurer, C. M., Lehnherr, A., Hotz, A. L., Forster, I. C., Gesemann, M., & Neuhauss, S. C. F. (2017). Shaping of signal transmission at the photoreceptor synapse by EAAT2 glutamate transporters. ENeuro, 4(3), e0339. https://doi.org/10.1523/ENEURO.0339-16.2017
