Publication: Spatio-temporally separated cortical flows and spindle geometry establish physical asymmetry in fly neural stem cells
Spatio-temporally separated cortical flows and spindle geometry establish physical asymmetry in fly neural stem cells
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Roubinet, C., Tsankova, A., Pham, T. T., Monnard, A., Caussinus, E., Affolter, M., & Cabernard, C. (2017). Spatio-temporally separated cortical flows and spindle geometry establish physical asymmetry in fly neural stem cells. Nature Communications, 8(1), 1383. https://doi.org/10.1038/s41467-017-01391-w
Abstract
Abstract
Abstract
Asymmetric cell division, creating sibling cells with distinct developmental potentials, can be manifested in sibling cell size asymmetry. This form of physical asymmetry occurs in several metazoan cells, but the underlying mechanisms and function are incompletely understood. Here we use Drosophila neural stem cells to elucidate the mechanisms involved in physical asymmetry establishment. We show that Myosin relocalizes to the cleavage furrow via two distinct cortical Myosin flows: at anaphase onset, a polarity induced, basally direct
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- Roubinet, Chantal
- Tsankova, Anna
- Pham, Tri Thanh
- Monnard, Arnaud
- Caussinus, Emmanuel
- Affolter, Markus
- Cabernard, Clemens
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Citations
Roubinet, C., Tsankova, A., Pham, T. T., Monnard, A., Caussinus, E., Affolter, M., & Cabernard, C. (2017). Spatio-temporally separated cortical flows and spindle geometry establish physical asymmetry in fly neural stem cells. Nature Communications, 8(1), 1383. https://doi.org/10.1038/s41467-017-01391-w
