HDL - a difficult friend

Abstract

High-density lipoprotein (HDL) is an attractive target for antiatherogenic drug therapy because of the inverse association between HDL cholesterol and cardiovascular risk as well as many potentially antiatherogenic functions. However, controversial data from inborn errors of human HDL metabolism and genetic animal models as well as the frequent confounding of low HDL cholesterol with other proatherogenic conditions in the population have complicated the proof of a causal relationship between HDL cholesterol and atherosclerosis. Becaus Show more