Publication: RIPK1/RIPK3 promotes vascular permeability to allow tumor cell extravasation independent of its necroptotic function
RIPK1/RIPK3 promotes vascular permeability to allow tumor cell extravasation independent of its necroptotic function
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Hänggi, K., Vasilikos, L., Valls, A. F., Yerbes, R., Knop, J., Spilgies, L. M., Rieck, K., Misra, T., Bertin, J., Gough, P. J., Schmidt, T., de Almodòvar, C. R., & Wong, W. W.-L. (2017). RIPK1/RIPK3 promotes vascular permeability to allow tumor cell extravasation independent of its necroptotic function. Cell Death and Disease, 8, e2588. https://doi.org/10.1038/cddis.2017.20
Abstract
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Abstract
Necroptosis is an inflammatory form of programmed cell death requiring receptor-interacting protein kinase 1, 3 (RIPK1, RIPK3) and mixed lineage kinase domain-like protein (MLKL). The kinase of RIPK3 phosphorylates MLKL causing MLKL to form a pore-like structure, allowing intracellular contents to release and cell death to occur. Alternatively, RIPK1 and RIPK3 have been shown to regulate cytokine production directly influencing inflammatory immune infiltrates. Recent data suggest that necroptosis may contribute to the malignant transf
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- Hänggi, Kay
- Vasilikos, Lazaros
- Valls, Aida Freire
- Yerbes, Rosario
- Knop, Janin
- Spilgies, Lisanne M
- Rieck, Kristy
- Misra, Tvisha
- Bertin, John
- Gough, Peter J
- Schmidt, Thomas
- de Almodòvar, Carmen Ruiz
- Wong, W Wei-Lynn
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Hänggi, K., Vasilikos, L., Valls, A. F., Yerbes, R., Knop, J., Spilgies, L. M., Rieck, K., Misra, T., Bertin, J., Gough, P. J., Schmidt, T., de Almodòvar, C. R., & Wong, W. W.-L. (2017). RIPK1/RIPK3 promotes vascular permeability to allow tumor cell extravasation independent of its necroptotic function. Cell Death and Disease, 8, e2588. https://doi.org/10.1038/cddis.2017.20
