Publication: Beyond the Paradigm: Novel Functions of Renin-Producing Cells
Beyond the Paradigm: Novel Functions of Renin-Producing Cells
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Steglich, A., Hickmann, L., Linkermann, A., Bornstein, S., Hugo, C., & Todorov, V. T. (2020). Beyond the Paradigm: Novel Functions of Renin-Producing Cells. Reviews of Physiology, Biochemistry and Pharmacology, 177, 53–81. https://doi.org/10.1007/112_2020_27
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The juxtaglomerular renin-producing cells (RPC) of the kidney are referred to as the major source of circulating renin. Renin is the limiting factor in renin-angiotensin system (RAS), which represents a proteolytic cascade in blood plasma that plays a central role in the regulation of blood pressure. Further cells disseminated in the entire organism express renin at a low level as part of tissue RASs, which are thought to locally modulate the effects of systemic RAS. In recent years, it became increasingly clear that the renal RPC are
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- Steglich, Anne
- Hickmann, Linda
- Linkermann, Andreas
- Bornstein, Stefan
- Hugo, Christian
- Todorov, Vladimir T
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Steglich, A., Hickmann, L., Linkermann, A., Bornstein, S., Hugo, C., & Todorov, V. T. (2020). Beyond the Paradigm: Novel Functions of Renin-Producing Cells. Reviews of Physiology, Biochemistry and Pharmacology, 177, 53–81. https://doi.org/10.1007/112_2020_27