Publication: Acute regulated expression of pendrin in human urinary exosomes
Acute regulated expression of pendrin in human urinary exosomes
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Pathare, G., Dhayat, N., Mohebbi, N., Wagner, C. A., Cheval, L., Neuhaus, T. J., & Fuster, D. G. (2018). Acute regulated expression of pendrin in human urinary exosomes. Pflügers Archiv : European Journal of Physiology, 470(2), 427–438. https://doi.org/10.1007/s00424-017-2049-0
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It is well known that pendrin, an apical Cl(-)/HCO3(-)exchanger in type B intercalated cells, is modulated by chronic acid-base disturbances and electrolyte intake. To study this adaptation further at the acute level, we analyzed urinary exosomes from individuals subjected to oral acute acid, alkali, and NaCl loading. Acute oral NH4Cl loading (n = 8) elicited systemic acidemia with a drop in urinary pH and an increase in urinary NH4 excretion. Nadir urinary pH was achieved 5 h after NH4Cl loading. Exosomal pendrin abundance was dramat
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- Pathare, Ganesh
- Dhayat, Nasser
- Mohebbi, Nilufar
- Wagner, Carsten A
- Cheval, Lydie
- Neuhaus, Thomas J
- Fuster, Daniel G
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Pathare, G., Dhayat, N., Mohebbi, N., Wagner, C. A., Cheval, L., Neuhaus, T. J., & Fuster, D. G. (2018). Acute regulated expression of pendrin in human urinary exosomes. Pflügers Archiv : European Journal of Physiology, 470(2), 427–438. https://doi.org/10.1007/s00424-017-2049-0
