Publication: Phenotypic deficits in the HIV-1 envelope are associated with the maturation of a V2-directed broadly neutralizing antibody lineage
Phenotypic deficits in the HIV-1 envelope are associated with the maturation of a V2-directed broadly neutralizing antibody lineage
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Reh, L., Magnus, C., Kadelka, C., Kühnert, D., Uhr, T., Weber, J., Morris, L., Moore, P. L., & Trkola, A. (2018). Phenotypic deficits in the HIV-1 envelope are associated with the maturation of a V2-directed broadly neutralizing antibody lineage. PLoS Pathogens, 14, e1006825. https://doi.org/10.1371/journal.ppat.1006825
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Abstract
Broadly neutralizing antibodies (bnAbs) to HIV-1 can evolve after years of an iterative process of virus escape and antibody adaptation that HIV-1 vaccine design seeks to mimic. To enable this, properties that render HIV-1 envelopes (Env) capable of eliciting bnAb responses need to be defined. Here, we followed the evolution of the V2 apex directed bnAb lineage VRC26 in the HIV-1 subtype C superinfected donor CAP256 to investigate the phenotypic changes of the virus populations circulating before and during the early phases of bnAb in
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- Reh, Lucia
- Magnus, Carsten
- Kadelka, Claus
- Kühnert, Denise
- Uhr, Therese
- Weber, Jacqueline
- Morris, Lynn
- Moore, Penny L
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Reh, L., Magnus, C., Kadelka, C., Kühnert, D., Uhr, T., Weber, J., Morris, L., Moore, P. L., & Trkola, A. (2018). Phenotypic deficits in the HIV-1 envelope are associated with the maturation of a V2-directed broadly neutralizing antibody lineage. PLoS Pathogens, 14, e1006825. https://doi.org/10.1371/journal.ppat.1006825
