Publication: Propagation of Plasma L-Phenylalanine Concentration Fluctuations to the Neurovascular Unit in Phenylketonuria: An in silico Study.
Propagation of Plasma L-Phenylalanine Concentration Fluctuations to the Neurovascular Unit in Phenylketonuria: An in silico Study.
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Taslimifar, M., Buoso, S., Verrey, F., & Kurtcuoglu, V. (2019). Propagation of Plasma L-Phenylalanine Concentration Fluctuations to the Neurovascular Unit in Phenylketonuria: An in silico Study. Frontiers in Physiology, 10, 360. https://doi.org/10.3389/fphys.2019.00360
Abstract
Abstract
Abstract
Phenylketonuria (PKU) is an inherited metabolic disease characterized by abnormally high concentrations of the essential amino acid L-phenylalanine (Phe) in blood plasma caused by reduced activity of phenylalanine hydroxylase (PAH). While numerous studies have shown association between high plasma Phe concentration and intellectual impairment, it is not clear whether increased Phe fluctuations also observed in PKU affect the brain as well. To investigate this, time-resolved data on Phe and competing large neutral amino acid (LNAA) co
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- Taslimifar, Mehdi
- Buoso, Stefano
- Verrey, Francois
- Kurtcuoglu, Vartan
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Citations
Taslimifar, M., Buoso, S., Verrey, F., & Kurtcuoglu, V. (2019). Propagation of Plasma L-Phenylalanine Concentration Fluctuations to the Neurovascular Unit in Phenylketonuria: An in silico Study. Frontiers in Physiology, 10, 360. https://doi.org/10.3389/fphys.2019.00360
